Dr. Daniel Kaschek
Hermann-Herder-Str. 3
79104 Freiburg
| Office: | Institute of Physics, high-rise building, 210 |
| Phone: | +49 761 203 8531 |
| Email: | daniel.kaschek 'at'
physik.uni-freiburg.de |
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Dr. Daniel Kaschek
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| Address | Institute of Physics Hermann-Herder-Str. 3 79104 Freiburg |
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| Position |
Leader of the sub-group "Physical Methods in Systems Biology". | ||||||||
| Research |
Method development: | ||||||||
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Parameter estimation in differential equation models | ||||||||
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Uncertainty analysis by the profile-likelihood method | ||||||||
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Statistical properties of cost functionals and their application in input estimation | ||||||||
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Lie symmetries and structural parameter identifiability | ||||||||
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Differential geometry of least-squares estimation problems | ||||||||
| Applied research: | |||||||||
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The impact of therapeutic antibodies on the MAPK/PI3K pathways in HER2+/- breast cancer cell lines | ||||||||
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Effects of toxic compounds on NFkB and NRF2 signaling | ||||||||
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The impact of cholestatic drugs on bile acid transport | ||||||||
| Software |
List of R/Python packages I am working on: | ||||||||
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blotIt2 (alignment of immunoblot and protein array data by mixed effects models, last update: Dec. 9, 2016) | ||||||||
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calibrator (calibration of protein array and luminex data, last update: Sep. 18, 2013) | ||||||||
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cOde (Interface between C and the deSolve package for R, hosted on GitHub) | ||||||||
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dMod (Framework for dynamic modeling and parameter estimation in R, hosted on GitHub) | ||||||||
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Lie symmetry detection (Direct search algorithm for the detection of Lie point symmetries, Dec. 14, 2015, Author: Benjamin Merkt) | ||||||||
| date: 02.11.2016 |