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Research interests: |
- Application of concepts from physics and mathematics to understand and influence processes in the life sciences |
- Numerical and statistical methodology for nonlinear modeling, parameter estimation and uncertainty analysis |
- Processing and analysis of quantitative biological data |
- Signaling pathways in the erythropoietic system |
- Prediction of clinical effects from signal processing on molecular level |
- Modeling of erythroid and cancer cells to discover drug target candidates |
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Publications: |
- Maiwald T, Hass H, Steiert B, Vanlier J, Engesser R, Raue A, Kipkeew F, Bock HH, Kaschek D, Kreutz C, Timmer J (2016) |
Driving the model to its limit: profile likelihood based model reduction |
PLoS ONE 11(9): e0162366. doi:10.1371/journal.pone.0162366 |
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- Steiert B, Timmer J, Kreutz C (2016) |
L1 regularization facilitates detection of cell type-specific parameters in dynamical systems |
Bioinformatics (2016) 32(17): i718-i726. doi:10.1093/bioinformatics/btw461 |
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- Merkle R, Steiert B, Salopiata F, Depner S, Raue A, Iwamoto N, Schelker M, Hass H, Wäsch M, Böhm ME, Mücke O, Lipka DB, Plass C, Lehmann WD, Kreutz C, Timmer J, Schilling M, Klingmüller U (2016) |
Identification of Cell Type-Specific Differences in Erythropoietin Receptor Signaling in Primary Erythroid and Lung Cancer Cells |
PLoS Comput Biol 12(8): e1005049. doi:10.1371/journal.pcbi.1005049 |
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- Raue A, Steiert B, Schelker M, Kreutz C, Maiwald T, Hass H, Vanlier J, Tönsing C, Adlung L, Engesser R, Mader W, Heinemann T, Hasenauer J, Schilling M, Höfer T, Klipp E, Theis F, Klingmüller U, Schoberl B, Timmer J (2015) |
Data2Dynamics: a modeling environment tailored to parameter estimation in dynamical systems |
Bioinformatics (2015) 31(21): 3558-3560. doi:10.1093/bioinformatics/btv405 |
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- Karr JR, Williams AH, Zucker JD, Raue A, Steiert B, Timmer J, Kreutz C, DREAM8 Parameter Estimation Challenge Consortium, Wilkinson S, Allgood BA, Bot BM, Hoff BR, Kellen MR, Covert MW, Stolovitzky GA, Meyer P (2015) |
Summary of the DREAM8 Parameter Estimation Challenge: Toward Parameter Identification for Whole-Cell Models |
PLoS Comput Biol 11(5): e1004096. doi:10.1371/journal.pcbi.1004096 |
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- Meyer P, Cokelaer T, Chandran D, Kim K, Loh P, Tucker G, Lipson M, Berger B, Kreutz C, Raue A, Steiert B, Timmer J, Bilal E, Sauro H, Stolovitzky G, Saez-Rodriguez J (2014) |
Network Topology and Parameter Estimation: From Experimental Design Methods to Gene Regulatory Network Kinetics using a Community based Approach |
BMC Systems Biology 2014, 8:13. doi:10.1186/1752-0509-8-13 |
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- Steiert B, Raue A, Timmer J, Kreutz C (2012) |
Experimental Design for Parameter Estimation of Gene Regulatory Networks |
PLoS ONE 7(7): e40052. doi:10.1371/journal.pone.0040052 |
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Curriculum Vitae: |
03/2017 - 09/2017 | PostDoc in physics in the group of Prof. Dr. Jens Timmer |
08/2012 - 03/2017 | Doctoral candidate in physics in the group of Prof. Dr. Jens Timmer |
10/2013 - 03/2014 | Visiting PhD student in the group of Prof. Dr. Peter Sorger at Harvard Medical School |
01/2011 - 07/2012 | Diploma candidate in physics in the group of Prof. Dr. Jens Timmer |
04/2009 - 10/2009 | Internship at Porsche Engineering |
01/2008 - 07/2012 | Graduate student in physics at University of Freiburg |
10/2005 - 01/2008 | Undergraduate student in physics at University of Freiburg |
07/2005 | Abitur at Richard-Fehrenbach Gewerbeschule Freiburg |
04/1986 | Born in Freiburg, Baden-Württemberg |
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