Applications

Epo receptor model (download)

The model is based on a subset of experiments and models introduced in Becker, Science 2010. The model was used in Raue, Chaos 2010 to exemplify the application of the Profile Likelihood and experimental design approaches. Furthermore, the model was used to compare the results of the Profile Likelihood Approach to results obtained by Markov-chain Monte Carlo sampling in Raue, Phil. Trans. Roy. Soc. A 2013. The model is available as stand alone MATLAB function. The link of model and data for the initial and extended stages of experimental setup are included and can be evaluated conveniently. A documentation of how to use the code is included.

JAK-STAT signaling pathway (download)

The Profile Likelihood Approach was applied to a JAK-STAT signaling pathway model that is based on Swameye, Proceedings of the National Academy of Sciences 2003. The results are described in Raue, Bioinformatics 2009. The application is set up in the PottersWheel format, see in Profile Likelihood Approach for details.

Simple example model (download)

The model was used in Raue, IET Systems Biology 2011 to exemplify the application of the Profile Likelihood, experimental design and model reduction approaches. The application is set up in the PottersWheel format, see in Profile Likelihood Approach for details.