Dr. Daniel Kaschek
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Address | Institute of Physics Hermann-Herder-Str. 3 79104 Freiburg |
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Position |
Leader of the sub-group "Physical Methods in Systems Biology". | ||||||||
Research |
Method development: | ||||||||
Parameter estimation in differential equation models | |||||||||
Uncertainty analysis by the profile-likelihood method | |||||||||
Statistical properties of cost functionals and their application in input estimation | |||||||||
Lie symmetries and structural parameter identifiability | |||||||||
Differential geometry of least-squares estimation problems | |||||||||
Applied research: | |||||||||
The impact of therapeutic antibodies on the MAPK/PI3K pathways in HER2+/- breast cancer cell lines | |||||||||
Effects of toxic compounds on NFkB and NRF2 signaling | |||||||||
The impact of cholestatic drugs on bile acid transport | |||||||||
Software |
List of R/Python packages I am working on: | ||||||||
blotIt2 (alignment of immunoblot and protein array data by mixed effects models, last update: Dec. 9, 2016) | |||||||||
calibrator (calibration of protein array and luminex data, last update: Sep. 18, 2013) | |||||||||
cOde (Interface between C and the deSolve package for R, hosted on GitHub) | |||||||||
dMod (Framework for dynamic modeling and parameter estimation in R, hosted on GitHub) | |||||||||
Lie symmetry detection (Direct search algorithm for the detection of Lie point symmetries, Dec. 14, 2015, Author: Benjamin Merkt) | |||||||||
date: 02.11.2016 |