Systems Biology University of Freiburg
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Helge Hass

University of Freiburg
Institute of Physics
Hermann-Herder-Straße 3
High-rise, room 208
79104 Freiburg
helgehass ät
Tel +49 761 203 8533


Research Interests:
  • Mathematical modelling of RTK crosstalk mechanisms in cancer.
  • Linking model-derived features to cell fate via machine learning
  • Modelling of early dynamics in the Reelin signalling cascade
  • Establishing a gene network for developmental timing in early Zebrafish embrios through Pou/Sox transcription factors
  • Approximation of prediction and validation bands via integration methods with adapted correction mechanisms (Download of analytical ABC example)
  • Integration and optimisation techniques, sensitivity computation
  • Co-Developer of open-source
Projects involved in:
LungSys II
BIOSS Centre for Biological Signalling Studies

D. Kurzhunov, R. Borowiak, H. Hass, P. Wagner, A. Krafft, J. Timmer M. Bock, (2016)
In vivo quantification of oxygen metabolic rates in the human brain with dynamic 17 O MRI: profile likelihood analysis.
Magnetic Resonance in Medicine (2016) In press(X)
T. Maiwald, H. Hass, B. Steiert (shared), J. Vanlier, R. Engesser, A. Raue, F. Kipkeew, H.H. Bock, D. Kaschek, C. Kreutz, J. Timmer, (2016)
Driving the model to its limit: profile likelihood based model reduction.
PloS ONE (2016) 11(9)
R. Merkle, B. Steiert, F. Salopiata, S. Depner, A. Raue, N. Iwamoto, M. Schelker, H. Hass, M. Wäsch, M. Böhm, O. Mäcke, D.B. Lipka, C. Plass, W.D. Lehmann, C. Kreutz, J. Timmer, M. Schilling, U. Klingmüller, (2016)
Identification of cell type-specific differences in erythropoietin receptor signaling in primary erythroid and lung cancer cells.
PloS Comp. Biology (2016) 12(8):
Hass, H, Kreutz C, Timmer J, Kaschek D, (2016)
Fast integration-based prediction bands for ordinary differential equation models
Bioinformatics (2016) 32(8): 1204-1210
Raue A, Steiert B, Schelker M, Kreutz C, Maiwald T, Hass H, Vanlier J, Tönsing C, Adlung L, Engesser R, Mader W, Heinemann T, Hasenauer J, Schilling M, Höfer T, Klipp E, Theis F, Klingmüller U, Schoberl B, Timmer J, (2015)
Data2Dynamics: a modeling environment tailored to parameter estimation in dynamical systems
Bioinformatics (2015) 31(21): 3558-3560.

10/2016PosterFrontiers of Systems Biology in Engineering: FOSBE2016
06/2016PosterConference of Systems Biology of Human Disease: SBHD2016
07/2015PosterConference of Systems Biology of Human Disease: SBHD2015
09/2014PosterAnnual meeting of e:Bio consortium
05/2014PosterConference of Systems Biology of Mammalian Cells: SBMC2014
02/2014PosterAdvanced Lecture Course on Systems Biology
Alumni Award 2014 from the University of Freiburg
10/08 - 04/13: Scholarship awarded from Friedrich-Ebert-Stiftung
01/08 - 04/13: Scholarship awarded from
Curriculum Vitae:
detailed CV
02/2016 - 09/2016Intern at Merrimack Pharmaceuticals, Boston, MA, USA
since 01/2014PhD student in the group of Prof. Dr. Jens Timmer, Albert-Ludwigs-Universität Freiburg
10/2005 - 04/2013Student of physics at Albert-Ludwigs-Universität Freiburg
Diploma Thesis (advisor Prof. Dr. Karl Jakobs):
10/2007 - 07/2011Bachelor study of economics at Albert-Ludwigs-Universität Freiburg
Data 2 Dynamics Software
Internal wiki of Timmer group